Publication | OcularConsultant

Peer-reviewed publications

1.Shyamanga Borooah, Anil Chekuri, Shikha Pachauri, Bhubanananda Sahu, Marina Vorochikhina, John J Suk, Dirk-Uwe Bartsch, Venkata R M Chavali, Monica M Jablonski, Radha Ayyagari., A Novel Mouse Model for Late-Onset Retinal Degeneration (L-ORD) Develops RPE Abnormalities Due to the Loss of C1qtnf5/Ctrp5. Adv Exp Biol. Book Series July 14; 1415:335-340 (2023)

2.Bhubanananda Sahu, Isha Chug, Hemant Khanna., The Ocular Gene Delivery Landscape Biomolecules. Aug 1;11(8):1135 (2021).

3.Bhubanananda Sahu, Laura Moreno Leon, Wei Zhang, Nikita Puranik, Ramesh Periasamy, Hemant Khanna, and Michael Volkert, Oxidative Stress Resistance 1 Gene Therapy Retards Neurodegeneration in the rd1 Mutant Mouse Model of Retinopathy. Invest Ophthalmol Vis Sci. Sep 2; 62 (12) :8 (2021)

4.Chan YK, Wang SK, Chu CJ, Copland DA, Letizia AJ, Costa Verdera H, Chiang JJ, Sethi M, Wang MK, Neidermyer WJ Jr, Chan Y, Lim ET, Graveline AR, Sanchez M, Boyd RF, Vihtelic TS, Inciong RGCO, Slain JM, Alphonse PJ, Xue Y, Robinson-McCarthy LR, Tam JM, Jabbar MH, Bhubanananda Sahu, Adeniran JF, Muhuri M, Tai PWL, Xie J, Krause TB, Vernet A, Pezone M, Xiao R, Liu T, Wang W, Kaplan HJ, Gao G, Dick AD, Mingozzi F, McCall MA, Cepko CL, Church GM., Engineering adeno-associated viral vectors to evade innate immune and inflammatory responses. Sci Transl Med. Feb 10;13(580) (2021)

5. Moreno-Leon L, West EL, O'Hara-Wright M, Li L, Nair R, He J, Anand M, Bhubanananda Sahu, Chavali VRM, Smith AJ, Ali RR, Jacobson SG, Cideciyan AV, Khanna H., RPGR isoform imbalance causes ciliary defects due to exon ORF15 mutations in X-linked retinitis pigmentosa (XLRP). Hum Mol Genet.Jan 21;29(22):3706-3716 (2021)

6. Chekuri A*, Bhubanananda Sahu*, Chavali VRM, Voronchikhina M, Soto-Hermida A, Suk JJ, Alapati AN, Bartsch DU, Ayala-Ramirez R, Zenteno JC, Dinculescu A, Jablonski MM, Borooah S, Ayyagari R. Long-Term Effects of Gene Therapy in a Novel Mouse Model of Human MFRP-Associated Retinopathy. Hum Gene Ther. Jan 16 *Equally contributed (2019)

7.Rakshit T, Senapati S, Parmar VM, Bhubanananda Sahu, Maeda A, Park PS. Adaptations in rod outer segment disc membranes in response to environmental lighting conditions. Biochim Biophys Acta. Jun 20; 1864(10): 1691-1702 (2017)

8. Yunlu Xue, Shinya Sato, David Razafsky, Bhubanananda Sahu, Susan Q. Shen, Lisa Sandell, Joseph C. Corbo, Krzysztof Palczewski, Akiko Maeda, Didier Hodzic, and Vladimir J. Kefalov, The role of retinol dehydrogenase 10 in the cone visual cycle. Scientific reports. 2017 May 24; 7(1): 2390 (2017)

9. Da Sun, Bhubanananda Sahu, Songqi Gao, Rebecca Schur, Akiko Maeda, Krzysztof Palczewski, Zheng-Rong Lu. Targeted Multifunctional Lipid ECO Plasmid DNA Nanoparticles as Efficient Non-Viral Gene Therapy for Leber's Congenital Amaurosis, Mol Ther Nucleic Acids. Jun 16; 7: 42–52 (2017)

10. Eisuke Arai, Vipulkumar Parmar Bhubanananda Sahu, Lindsay Perusek, Paul Tesar, and Akiko Maeda Docosahexaenoic acid promotes differentiation of photoreceptor cells in three-dimensional neural retinas. Neurosci Res. Apr 19. pii: S0168-0102(16)30318-2 (2017)

11.Sundermeier TR, Sakami S, Bhubanananda Sahu, Howell SJ, Gao S, Dong Z, Golczak M, Maeda A, Palczewski K. microRNA-processing Enzymes Are Essential for Survival and Function of Mature Retinal Pigmented Epithelial Cells in Mice. J Biol Chem. Jan 19. pii: jbc.M116.770024. doi: 10.1074 (2017)

12. Bhubanananda Sahu, Maeda A. Retinol Dehydrogenases Regulate Vitamin A Metabolism for Visual Function. Nutrients. Nov 22; 8 (11) (2016)

13. Parmar T. Parmar VM, Arai E, Bhubanananda Sahu, Lindsay Perusek, Akiko Maeda. Acute Stress Responses Are Early Molecular Events of Retinal Degeneration in Abca4-/-Rdh8-/- Mice After Light Exposure. Invest Ophthalmol Vis Sci. Jun 1:57 (7): 3257-67 (2016)

14. Bhubanananda Sahu, Wenyu Sun, Lindsay Perusek, Vipul Parmar, Yun-Zheng Le, Michael D. Griswold, Krzysztof Palczewski, Akiko Maeda. Conditional Ablation of Retinol Dehydrogenase 10 in the Retinal Pigmented Epithelium Causes Delayed Dark Adaption in Mice. J Biol Chem. Nov 6; 290(45): 27239-47 (2015)

15. Lindsay Perusek, Bhubanananda Sahu, Tanu Parmar, Hiroshi Maeno, Eisuke Aria, Yun-Zheng Le, Carlos Subauste, Yu Chen, Krzysztof Palczewski, Akiko Maeda, A2E accumulation and visual function are independent of Atg7-mediated autophagy in the retinal pigmented epithelium. J Biol Chem. Nov 27; 290(48): 29035-44. (2015)

16. Rebecca M. Schur, Li Sheng, Bhubanananda Sahu, Guanping Yu, Songqi Gao, Xin Yu, Akiko Maeda, Krzysztof Palczewski and Zheng-Rong Lu. Manganese-Enhanced MRI for Preclinical Evaluation of Retinal Degeneration Treatments. Invest Ophthalmol Vis Sci. Jul; 56(8): 4936-42 (2015)

17. Bhubanananda Sahu, Chavali VR, Alapati A, Suk J, Bartsch DU, Jablonski MM, Ayyagari R. Presence of rd8 mutation does not alter the ocular phenotype of late-onset retinal degeneration mouse model. Mol Vis. Mar 13; 21:273-84. (2015)

18. Sharma R, Bhubanananda Sahu, Ray MK, Deshmukh MV. Backbone and stereospecific 13C methyl Ile (δ1), Leu and Val side-chain chemical shift assignments of Crc. Biomol NMR Assign. Apr; 9(1): 75-9 (2015)

19. Bhubanananda Sahu, Prashant K. Khade, and Simpson Joseph. Functional Replacement of Two Highly Conserved Tetraloops in the Bacterial Ribosome Biochemistry, Sep 25;51(38):7618-26. (2012)

20. Bhubanananda Sahu, Prashant K. Khade and Simpson Joseph. Highly Conserved Base A55of16S Ribosomal RNA is Important for the Elongation Cycle of Protein Synthesis. Biochemistry.Sep24; 52(38): 6695-6701 (2013)

21. Bhubanananda Sahu and Ray M. K. Auxotrophy in natural isolate: minimal requirements for growth of the Antarctic psychrotrophic bacterium Pseudomonas syringae Lz4W. Journal of Basic Microbiology, Feb; 48(1): 38-47. (2008)

Book chapter

22. Bhubanananda Sahu, Maeda A. RPE visual cycle and Biochemical Phenotypes of Mutant Mouse models. Methods Mol Biol.; 1753:89-102. Book chapter (2018)

Invited Presentations

1.A MiniCEP290 Gene Replacement Therapy to Treat CEP 290-Leber Congenital Amourosis (LCA10), Iveric Bio, 2022

2.The alternative RPGR isoform RPGRconst, not implicated in X-linked RP, plays a crucial role in mammalian retina, Investigative Ophthalmology and Visual Science, Baltimore, MD, 2020

3. Conditional ablation of Rdh10 in retinal pigment epithelium delay dark adaption in mouse, Visual Sciences Research Center Annual Symposium, CWRU, Cleveland,2015

4. Loss of Retinol Dehydrogenase 10 (Rdh10) in Retinal Pigment Epithelium Leads to Delayed Dark Adaption in mice, Research showcase, CWRU, Cleveland,2015

5. Conditional ablation of Rdh10 in retinal pigment epithelium delays dark adaption in mouse,2015

6. A knock-in mouse model for recessive RP-foveoschisis-optic disc drusen and nanophthalamos syndrome due to a mutation in the Mfrp gene, Seattle, Washington,2013

Conference Presentations

International

1. Rebecca M Schur, Li Sheng, Bhubanananda Sahu, Guanping Yu, Song-Qi Gao, Xin Yu, Akiko Maeda, Krzysztof Palczewski, and Zheng-Rong Lu Manganese-Enhanced MRI for Preclinical Evaluation of Therapeutic Efficacy of Retinal Degeneration Treatment. International Society for Magnetic Resonance in Medicine (ISMRM) 23rd Annual Meeting & Exhibition, 30 May - 05 June 2015 Toronto, Ontario, Canada.

National

1.Mohona Gupta, Bhubanananda Sahu, Payam Khoshkenar, Raju VS Rajala, and Hemant Khanna, Trafficking of phosphoinositide regulators in sensory cilia., 2020 University of Massachusetts Medical School Research Retreat,2021

2.Vincent Thoren, Bhubanananda Sahu, Radhika Duvvuri, Laura MorenoLeon, Mahesh Shivanna, Hemant Khanna. Genome editing of the iCEP290i Gene in Pig Cells A Step towards Generating a Large Animal Model of Childhood Blindness Disorder Leber Congenital Amaurosis LCA, American Academy of Optometry,2020

3.Bhubanananda Sahu, Wei Zhang, Laura Moreno-Leon, Linjing Li, Ramesh Periasamy, Manisha Anand, Michael Brodsky and Hemant Khanna, The RPGR isoform not implicated in human retinal disease plays a crucial role in mammalian retina, FASEB,2019

4.Mike Volkert, Bhubanananda Sahu, Hemant Khanna. OXR1 (oxidation resistance gene 1) Reduces Oxidative Stress and Prolongs Photoreceptor Survival in Retinal Degeneration, ARVO,2019

5. McCall, M.A., Jalligampala, A. Pangeni, G. Kaplan, H.J., Wang, W. Bhubanananda, Sahu., Chatterton, J.E., Smith, J., Bartsevich, V., Viles, K. Allele-specific Gene Editing Induces Rod Function in a Transgenic Swine Model of Autosomal Dominant Retinitis Pigmentosa. ARVO,2019

6.Chan, Y.K., Wang, S., Letizia, A. Chang, Y., Lim, E. Graveline, A., Costa Verdera, H., Alphonse, P., Xue, U., Chiang, J., Robinson-McCarthy, L., Tam, J., Jabbar., M., Bhubanananda, Sahu., Adeniran, J., Nuhuri, M., Tai, P., Xie, J., Krause, T., Vernet A., Pezone, M., Xiao, R., Liu, T., Wang, W., Kaplan, H., Gao, G., Mingozzi, F., McCall, M.A., Cepko, C., Church, G., Reducing AAV-Mediated Immune Responses and Pathology in a Subretinal Pig Model by Engineering the Vector Genome (American Society of Gene and Cell Therapy (ASGCT),2019

7.Brown, R.V., Kollu, N., Jalligampala, A., Jabbar, M.H. Pangeni, G., Bhubanananda, Sahu., Kaplan, H.J., Wang, W., Fleissig, E., Chatterton, J.E. McCall, M.A., Viles, K., Hirsch, M., Bartsevich, V., Smith, J., Beard, C., Jantz, D., Therapeutic Efficacy of ARCUS Meganuclease Gene Editing for Autosomal Dominant Retinitis Pigmentosa (ASGCT),2019

8.Bhubanananda Sahu, Tanu Parmar, Akiko Maeda, Oncostatin M receptor up-regulation in Abca4-/-Rdh8-/- mice, a murine model of human age-related macular degeneration (AMD). Visual Science Research Symposium, CWRU, Cleveland, OH,2016

9.Thomas Sundermeier, Bhubanananda Sahu, Akiko Maeda, Krzysztof Palczewski. Dissecting the miRNA-regulated gene networks governing the survival and function of photoreceptors and the RPE. Visual Science Research Center Annual Symposium, Department of Ophthalmology and Visual Sciences, Case Western Reserve University,2016

10. Radha Ayyagari, Bhubanananda Sahu, Akhila Alapati, John Suk, Dirk-Uwe G Bartsch, Monica M. Jablonski, Venkata R.M. Chavali. Presence of rd8 mutation does not affect the Late-Onset Retinal Degeneration (L-ORD) phenotype in C57BL/6 mice with S163R Ctrp5/C1qtnf5 mutation. Investigative Ophthalmology and Visual Science,2015

11. Akiko Maeda, Lindsay Perusek, Bhubanananda Sahu, Eisuke Arai, Krzysztof Palczewski, Yu Chen. A2E accumulation and autophagy in the RPE of Mice. The Federation of American Societies for Experimental Biology (FASEB), Biology and Chemistry of Vision Conference,2015

12. Da Sun, Bhubanananda Sahu, Song-Qi Gao, Akiko Maeda, Krzysztof Palczewski, Zheng-Rong Lu, Retinylamine Modified Multifunctional Lipid DNA Delivery System for the Treatment of LCA2. Biomedical engineering society (BMES) 2015 annual meeting, Tampa, Florida,2015

13. Eisuke Arai, Lindsay Perusek, Bhubanananda Sahu, Akiko Maeda. Towards understanding roles RDS in Stargardt disease. 2015 Visual Science Research Center Annual Symposium, Department of Ophthalmology and Visual Science, Case Western Reserve University, Cleveland, Ohio,2015

14. Lindsay Perusek, Bhubanananda Sahu, Eisuke Aria, Akiko Maeda. Implications for autophagy in retinal pigmented epithelium cell health. 2015 Visual Science Research Center Annual Symposium, Department of Ophthalmology and Visual Science, Case Western Reserve University, Cleveland, Ohio,2015

15. Bhubanananda Sahu, Tadao Maeda, Wenyu Sun, Akiko Maeda. Characterization of Retinol Dehydrogenase 10 (RDH10) (2014). Visual Sciences Research Center Annual Symposium, CWRU, Cleveland,2014

16. Astra Dinculescu, Seok-Hong Min, Wen-Tao Deng, Jie Li, Renee Ryals, Rachel Stupay, Ping Zhu, Bhubanananda Sahu, Radha Ayyagari, William Hauswirth. CTRP5 over-expression in RPE cells leads to loss of RPE cell adhesion and retinal degeneration in wild-type mice. Investigative Ophthalmology and Visual Science,2013

17. Bhubanananda Sahu (2013). RDH10 expressed in insect cells catalyzes the reaction from atRAL to atROL. The Department of Pharmacology Retreat, Kalahari Resort Sandusky, OH,2013

18. Astra Dinculescu, Seok-Hong Min, Wen-Tao Deng, Jie Li, Renee Ryals, Rachel Stupay, Ping Zhu, Bhubanananda Sahu, Radha Ayyagari, William Hauswirth. CTRP5 over-expression in RPE cells leads to loss of RPE cell adhesion and retinal degeneration in wild-type mice. Annual Research Day, May 17, 2013, at UC San Diego Department of Ophthalmology and Shiley Eye Center, 2013

19. Venkata R. Chavali, Bhubanananda Sahu, Dirk-Uwe Bartsch, Tarun Bansal, Chrisrine A. Curcio, Sheldon S. Miller, Monica M. Jablonski, Radha Ayyagari. Absence of Ctrp5/c1qtnf5 Leads to RPE Degeneration in Ctrp5 Gene Knock-out Mice. Investigative Ophthalmology and Visual Science,2012

20. Radha Ayyagari, Bhubanananda Sahu, Igor Kozak, Sangeetha Vishweswaraiah, Henry A. Ferreyra, Venkata, Harini Gudiseva, Sandra Soares, Pauline Lee, S Amer Riazuddin, Terry Gaasterland. Genetics Analysis of Simplex Retinal Dystrophy Patients Using Exome Sequencing. Investigative Ophthalmology and Visual Science,2012